A Fatal Case of Naegleria fowleri ... | 疾病管制署傳染病

由MYSu著作·2013·被引用20次—Thisisthefirstcaseofprimaryamebicmeningoencephalitis(PAM)causedbyNaegleriafowleriinTaiwan.PAMwasdiagnosedbasedondetectionofactively ...

After bathing at a hot spring resort, a 75-year-old man presented to the emergency department because of seizure-like attack with loss of conscious. This is the first case of primary amebic meningoencephalitis (PAM) caused by Naegleria fowleri in Taiwan. PAM was diagnosed based on detection of actively motile trophozoites in cerebrospinal fluid using a wet-mount smear and the Lius stain. The amoebae were further confirmed by PCR and gene sequencing. In spite of administering amphotericin B treatment, the patient died 25 days later.

Keywords: Naegleria fowleri, meningoencephalitis, fatal case, amphotericin B, Taiwan

Naegleria fowleri, Acanthamoeba spp., and Balamuthia mandrillaris have been recognized as etiologic agents of encephalitis [1,2]. N. fowleri causes primary amebic meningoencephalitis (PAM), a rapidly fatal disease, while Acanthamoeba spp. and B. mandrillaris cause chronic granulomatous encephalitis [3]. N. fowleri is commonly found in wa...